期刊
METABOLISM-CLINICAL AND EXPERIMENTAL
卷 58, 期 1, 页码 22-29出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.metabol.2008.09.002
关键词
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资金
- National Institutes of Health (NIH) [P20 RR16430, HL-091333, HL-075675, AT-002599, AT-002993, AT-003645, DK 074842]
- American Diabetes Association
- NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINE [R21AT002599, R21AT003645, R21AT002993] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR016430] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL091333, R01HL075675] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK074842] Funding Source: NIH RePORTER
Adiponectin, a protein secreted by adipose tissue, has antiatherogenic, anti-inflammatory, and insulin-sensitizing actions. We examined the relationship between plasma adiponectin and adiposity, insulin resistance, plasma lipids, glucose, leptin, and anthropometric measurements in 316 adult men and 353 adult women Yup'ik Eskimos in Southwest Alaska. Adiponectin concentration was negatively associated with body mass index, percentage of body fat. sum of skin folds, waist circumference, triglycerides, insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR]), fasting insulin, and leptin in both men and women, and also with glucose in women. Adiponectin concentration correlated positively with high-density lipoprotein cholesterol concentration, and also with low-density lipoprotein cholesterol in women. Insulin-sensitive individuals (HOMA-IR <3.52 n = 442) had higher plasma adiponectin concentrations than more insulin-resistant individuals (HOMA-IR >= 3.52, n = 224): 11.02 +/- 0.27 mu g/mL vs 8.26 +/- 0.32 mu g/mL P <.001. Adiponectin concentrations did not differ between groups Of participants with low and high level of risk for developing coronary heart disease. No difference in plasma adiponectin levels was found among Yup'ik Eskimos and whites matched for sex, age. and body mass index. fit Conclusion, circulating adiponectin concentrations were most strongly associated with sum of skin folds in Yup'ik men and with high-density lipoprotein cholesterol levels, sum of skin folds, waist cirumference, and insulin and triglycerides concentrations in Yup'ik women. (C) 2009 Elsevier Inc. All rights reserved.
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