期刊
METABOLIC ENGINEERING
卷 14, 期 4, 页码 394-400出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymben.2012.03.005
关键词
Ketones; Acetone; Biosynthesis; CO2; Synechocystis sp PCC 6803
资金
- National Basic Research Program of China (973) [2011CBA00803]
- National Natural Science Foundation of China [30970103]
- Beijing Natural Science Foundation of China [5102026]
- Hundreds of Talents Program of the Chinese Academy of Sciences
Ketones are a class of important organic compounds. As the simplest ketone, acetone is widely used as solvents or precursors for industrial chemicals. Presently, million tonnes of acetone is produced worldwide annually, from petrochemical processes. Here we report a biotechnological process that can produce acetone from CO2, by designing and creating a modularized synthetic pathway in engineered cyanobacterium Synechocystis sp. PCC 6803. The engineered Synechocystis cells are able to produce acetone (36.0 mg l(-1) culture medium) using CO2 as the sole carbon source, thus opens the gateway for biosynthesis of ketones from CO2. (C) 2012 Elsevier Inc. All rights reserved.
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