期刊
METABOLIC ENGINEERING
卷 10, 期 6, 页码 305-311出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymben.2007.08.003
关键词
Biofuel; Butanol; E. coli
资金
- UCLA-DOE Institute for Genomics and Proteomics
- UCLA-NASA CMISE Institute
Compared to ethanol, butanol offers many advantages as a substitute for gasoline because of higher energy content and higher hydrophobicity. Typically, 1-butanol is produced by Clostridium in a mixed-product fermentation. To facilitate strain improvement for specificity and productivity, we engineered a synthetic pathway in Escherichia coli and demonstrated the production of 1-butanol from this non-native user-friendly host. Alternative genes and competing pathway deletions were evaluated for 1-butanol production. Results show promise for using E. coli for 1-butanol production. (C) 2007 Elsevier Inc. All rights reserved.
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