期刊
METABOLIC BRAIN DISEASE
卷 27, 期 3, 页码 377-385出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11011-012-9298-6
关键词
Maternal separation; Voluntary exercise; Recognition memory; p-ERK; MKP-1
资金
- National Research Foundation
- National Institutes of Health Fogarty International Centre [R01TW008040]
Early life stress increases the risk of developing psychopathology accompanied by reduced cognitive function in later life. Maternal separation induces anxiety-like behaviours and is associated with impaired memory. On the other hand, exercise has been shown to diminish anxiety-like behaviours and improve cognitive function. The effects of maternal separation and exercise on anxiety, memory and hippocampal proteins were investigated in male Sprague-Dawley rats. Maternal separation produced anxiety-like behaviours which were reversed by exercise. Maternal separation also enhanced object location memory which was not affected by exercise. Exercise did, however, increase synaptophysin and phospho-extracellular signal-regulated kinase (p-ERK) in the hippocampus of non-separated rats and this effect was not observed in maternally separated rats. These findings show that maternal separation selectively enhanced n memory and prevented activation of the MAPK/ERK signalling pathway in the adult rat hippocampus.
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