期刊
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
卷 18, 期 10, 页码 1131-1142出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/gme.0b013e3182175b66
关键词
Estrogen receptor beta; Phytoestrogen; Menopause; Hot flashes; Hair loss; Cognition
资金
- Alzheimer's Association
- National Institute on Aging
- Bensussen Translational Research Fund
- USC Memory and Aging Center
Objective: As an alternative to estrogen therapy, the efficacy of an estrogen receptor beta-selective phytoestrogenic (phyto-beta-SERM) formulation to regulate climacteric symptoms and decline in brain responses associated with ovarian hormone loss in menopause was assessed. Methods: A phyto-beta-SERM formulation-containing diet was compared with a commercial soy extract diet and a phytoestrogen-free base/control diet in an ovariectomized (OVX) mouse model of human menopause. Two treatment studies were conducted: (1) a 2-month study assessed the effects of experimental diets on tail skin temperature as a model of menopausal hot flashes, and (2) a 9-month study assessed the long-term impact of the diets on overall health, hair thinning/loss, spatial working memory, and associated protein expression in the hippocampus. Results: The phyto-beta-SERM diet prevented OVX-induced menopause-like changes including the rise in skin temperature, hair thinning/loss, deficit in spatial memory function, and reversed OVX-induced decline in the expression of hippocampal proteins involved in neural plasticity and beta-amyloid degradation/clearance. The soy extract diet had no effect or exacerbated OVX-induced changes. Conclusions: Overall, the phyto-beta-SERM diet induced physical and neurological responses comparable with ovary-intact mice, suggesting the therapeutic potential of the phyto-beta-SERM formulation for the prevention/alleviation of climacteric symptoms and decline in brain responses induced by ovarian hormone loss, which provides the basis for further work in postmenopausal women.
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