期刊
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
卷 15, 期 4, 页码 726-729出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/gme.0b013e31816c5541
关键词
vaginal maturation index; sample self-collection; menopause
资金
- NIA NIH HHS [K23 AG024254] Funding Source: Medline
Objective: During menopause, the ratio of the three vaginal epithelial cell types (parabasal, intermediate, and superficial) changes. The proportion of these vaginal cell types is categorized by the vaginal maturation index (VMI). The VMI provides an objective assessment of vaginal hormone response as well as overall hormonal environment. The aim of this study was to determine the concordance of self- and physician-collected samples for VMI and evaluate participant preference for self-collection. Design: Twenty women aged 42 to 67 years were enrolled. Each woman received instructions and self-collected a sample for VMI analysis from her posterior lateral vaginal walls. Next, she underwent a vaginal speculum examination for physician VMI sampling. Finally, she completed a survey regarding sampling preference, ease of self-sampling, and previous vaginal experience. Correlation between physician- and self-collected samples were calculated using Pearson's correlation coefficient and Cronbach's alpha. Participant characteristics, vaginal experiences, and sampling preferences were summarized using frequencies and measures of central tendencies. The relationships between preference for sampling method and previous vaginal experiences were examined using Fisher's exact test. Results: Average age of the 20 participants was 52.2 years (range, 42-67 y). Women had a variety of previous vaginal experiences ranging from tampon use (100%) to previous vaginal self-swabbing (15%). Average self-collected VMI was 48.4 (range, 13.8-83.5) and physician-collected VMI was 49.9 (range, 20.5-83.5) with a correlation of 0.97 (P < 0. 001), alpha=0.94. The majority of women preferred self-collection (80%) to physician collection, and there was no difference in preference based on previous vaginal experiences. Nineteen women (95%) found the self-collection to be very easy, and one found it to be somewhat easy. Conclusions: Women can reliably self-collect samples for VMI, and the majority of women in our study preferred self-collection to physician collection. Vaginal self-sampling allows this technique for measuring overall hormonal environment to be used in clinical and epidemiological research.
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