期刊
MEMORIAS DO INSTITUTO OSWALDO CRUZ
卷 109, 期 5, 页码 644-661出版社
FUNDACO OSWALDO CRUZ
DOI: 10.1590/0074-0276130597
关键词
malaria; mosquito; Plasmodium; innate immunity
资金
- NIAID USA [AI031478]
- JHMRI
- Calvin S and Helen H Lang Post-doctoral fellowship
Nearly one million people are killed every year by the malaria parasite Plasmodium. Although the disease-causing forms of the parasite exist only in the human blood, mosquitoes of the genus Anopheles are the obligate vector for transmission. Here, we review the parasite life cycle in the vector and highlight the human and mosquito contributions that limit malaria parasite development in the mosquito host. We address parasite killing in its mosquito host and bottlenecks in parasite numbers that might guide intervention strategies to prevent transmission.
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