期刊
MEMORIAS DO INSTITUTO OSWALDO CRUZ
卷 106, 期 3, 页码 257-266出版社
FUNDACO OSWALDO CRUZ
DOI: 10.1590/S0074-02762011000300002
关键词
Trypanosoma cruzi; gene expression; post-transcriptional control; mRNA
资金
- CNPq
- FAPEMIG
- INCTV
- HHMI
Trypanosoma cruzi, a protozoan parasite that causes Chagas disease, exhibits unique mechanisms for gene expression such as constitutive polycistronic transcription of protein-coding genes, RNA editing and trans-splicing. In the absence of mechanism controlling transcription initiation, organized subsets of T. cruzi genes must be post-transcriptionally co-regulated in response to extracellular signals. The mechanisms that regulate stage-specific gene expression in this parasite have become much clearer through sequencing its whole genome as well as performing various proteomic and microarray analyses, which have demonstrated that at least half of the T. cruzi genes are differentially regulated during its life cycle. In this review, we attempt to highlight the recent advances in characterising cis and trans-acting elements in the T. cruzi genome that are involved in its post-transcriptional regulatory machinery.
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