期刊
MELANOMA RESEARCH
卷 21, 期 6, 页码 555-559出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CMR.0b013e32834bf398
关键词
KIT; mucosal melanoma; mutation; review
资金
- Russian Federation for Basic Research [11-04-01643, 10-04-92601, 10-04-00962]
- Federal Agency for Science and Innovations [16.512.11.2237]
- Commission of the European Communities [PITN-GA-2009-238132]
- Government of Moscow [15/11]
A single institution series of 48 mucosal melanomas (MMs) has been analyzed for the presence of KIT mutations using high-resolution melting and sequencing of abnormally melted DNA fragments. The analysis of exons 9, 11, 13, and 17 has revealed eight of 48 (17%) nonsynonymous alterations, including zero of seven head and neck, six of 24 anorectal, one of 15 genitourinary, one of one gastric, and zero of one mediastinal MMs. Seven of these mutations were potentially associated with the tumor sensitivity to KIT tyrosine kinase inhibitors. One tumor harbored somatically acquired silent nucleotide substitution c.1383A>G (T461T). This study adds to the evidence that a substantial portion of MMs carry a therapeutically relevant mutation in the KIT oncogene. Melanoma Res 21:555-559 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据