期刊
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
卷 41, 期 6, 页码 657-662出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1068162015060199
关键词
diazaadamantane; monoterpene; tyrosyl-DNA phosphodiesterase 1; inhibitor of DNA repair
资金
- [14.604.21.0018]
- [RFMEFI60414X0018]
The compounds containing diazaadamantane and monoterpene moieties have been found to inhibit human purified recombinant tyrosyl-DNA phosphodiesterase 1 (Tdp1), a DNA repair enzyme. Several compounds have been shown to be potent inhibitors of a new structural type. Improved inhibition efficiency has been observed for compounds with longer aliphatic chains and increased flexibility of substituent.
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