期刊
MEDICINE & SCIENCE IN SPORTS & EXERCISE
卷 43, 期 10, 页码 1828-1835出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/MSS.0b013e3182178bb4
关键词
GDF-8; ENDURANCE EXERCISE; RESISTANCE EXERCISE; METABOLISM
资金
- National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases
- National Institutes of Health from the National Institute of Arthritis, Musculoskeletal Diseases, and Stroke
- Natural Sciences and Engineering Research Council of Canada
ALLEN, D. L., D. S. HITTEL, and A. C. MCPHERRON. Expression and Function of Myostatin in Obesity, Diabetes, and Exercise Adaptation. Med. Sci. Sports Exerc., Vol. 43, No. 10, pp. 1828-1835, 2011. Myostatin is a member of the transforming growth factor-beta/bone morphogenetic protein (TGF-beta/BMP) superfamily of secreted factors that functions as a potent inhibitor of skeletal muscle growth. Moreover, considerable evidence has accumulated that myostatin also regulates metabolism and that its inhibition can significantly attenuate the progression of obesity and diabetes. Although at least part of these effects on metabolism can be attributable to myostatin's influence over skeletal muscle growth and therefore on the total volume of metabolically active lean body mass, there is mounting evidence that myostatin affects the growth and metabolic state of other tissues, including the adipose and the liver. In addition, recent work has explored the role of myostatin in substrate mobilization, uptake, and/or utilization of muscle independent of its effects on body composition. Finally, the effects of both endurance and resistance exercise on myostatin expression, as well as the potential role of myostatin in the beneficial metabolic adaptations occurring in response to exercise, have also begun to be delineated in greater detail. The purpose of this review was to summarize the work to date on the expression and function of myostatin in obesity, diabetes, and exercise adaptation.
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