期刊
RUSSIAN CHEMICAL BULLETIN
卷 64, 期 9, 页码 2210-2214出版社
SPRINGER
DOI: 10.1007/s11172-015-1140-y
关键词
p-tyrosol; 2-phenylethanol; 2-(4-nitrophenyl)ethyl nitrate; 2-(4-amino-phenyl)ethanol; 2-(4-hydroxyphenyl)ethanol; nitration; catalytic hydrogenation; nitrosation; antihypertensive activity; hemorheological activity; red blood cell aggregation; red blood cell deformability
资金
- Russian Science Foundation [14-25-00017]
- Russian Science Foundation [14-25-00017] Funding Source: Russian Science Foundation
A new method for the synthesis of p-tyrosol, i.e., 2-(4-hydroxyphenyl)ethanol, has been developed, which considerably simplified the process of preparation of this pharmaceutical substance. The method includes nitration of 2-phenylethanol, catalytic hydrogenation of 2-(4-nitrophenyl)ethyl nitrate, and nitrosation of 2-(4-aminophenyl)ethanol, followed by acid hydrolysis of the intermediate diazo compound. The method is easily feasible, furnishes the pharmaceutical substance of high quality, and is quite acceptable for commercialization. Antihypertensive and hemorheologic activities of p-tyrosol in spontaneously hypertensive rats were investigated per se and in combination with captopril. p-Tyrosol in the course administration with captopril was found to enhance the antihypertensive effect of the latter and eliminate its negative effect on red blood cell aggregation.
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