期刊
MEDICINE
卷 97, 期 39, 页码 -出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MD.0000000000011886
关键词
acute mountain sickness; computational approach; mechanism; Rhodiola rosea
资金
- Capital Medical Development [2014-2-5131]
Rhodiola rosea has been used in the treatment of acute mountain sickness (AMS) for a long time, but the mechanism of its action is not still completely clear. In this paper, the therapeutic mechanism of R rosea for AMS was investigated by analysis of the relationship between R rosea compositions and hypoxia-inducible factor 1 (HIF-1) degradation pathway. System biology and network biology, computational approaches were used to explore the molecular mechanisms of traditional Chinese medicine (TCM). Our results showed that chemical compositions of R rosea could inhibit the targets of HIF-1 degradation pathway in multicomposition/multi-target ways. We conclude that the 18 components with more than 2 targets and 5 targets (arrest-defective-1 [ARD1], forkhead transcription factor [FOXO4], osteosarcoma-9 [OS-9], prolyl hydroxylase 2 [PHD2], human double minute 2 [Hdm2]) deserve to be noticed, and PHD2, receptor for activated C-kinase1 (RACK1) and spermidine/spermine-N1-acetyltransferase-1 (SSAT1) may be the targets of active ingredients of rhodionin, rhodiosin, and rhodiolatuntoside, respectively.
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