相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Calcium Signalling and Alzheimer's Disease
Michael J. Berridge
NEUROCHEMICAL RESEARCH (2011)
Selective Acetylcholinesterase Inhibitor Activated by Acetylcholinesterase Releases an Active Chelator with Neurorescuing and Anti-Amyloid Activities
Hailin Zheng et al.
ACS CHEMICAL NEUROSCIENCE (2010)
Strategies for the Inhibition of Protein Aggregation in Human Diseases
Manuela Bartolini et al.
CHEMBIOCHEM (2010)
Development of an Efficient Therapeutic Agent for Alzheimer's Disease: Design and Synthesis of Dual Inhibitors of Acetylcholinesterase and Serotonin Transporter
Narihiro Toda et al.
CHEMICAL & PHARMACEUTICAL BULLETIN (2010)
Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates
Pelayo Camps et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2010)
Immune-Inflammatory Responses and Oxidative Stress in Alzheimers Disease: Therapeutic Implications
D. Bona et al.
CURRENT PHARMACEUTICAL DESIGN (2010)
GSK3: A possible link between beta amyloid peptide and tau protein
Felix Hernandez et al.
EXPERIMENTAL NEUROLOGY (2010)
Calcium Signaling and Amyloid Toxicity in Alzheimer Disease
Angelo Demuro et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Hybrid Molecules from Xanomeline and Tacrine: Enhanced Tacrine Actions on Cholinesterases and Muscarinic M1 Receptors
Lei Fang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Design, Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel Tacrine Derivatives with a Combination of Acetylcholinesterase Inhibition and Cannabinoid CB1 Receptor Antagonism
Jos H. M. Lange et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Design, Synthesis, and Biological Evaluation of a Novel Class of γ-Secretase Modulators with PPARγ Activity
Martina Hieke et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Bivalent β-Carbolines as Potential Multitarget Anti-Alzheimer Agents
Yvonne Rook et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Naturally occurring phytochemicals for the prevention of Alzheimer's disease
Jiyoung Kim et al.
JOURNAL OF NEUROCHEMISTRY (2010)
A New Tacrine-Melatonin Hybrid Reduces Amyloid Burden and Behavioral Deficits in a Mouse Model of Alzheimer's Disease
Carlos Spuch et al.
NEUROTOXICITY RESEARCH (2010)
Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process
Bart De Strooper
PHYSIOLOGICAL REVIEWS (2010)
ER Calcium and Alzheimer's Disease: In a State of Flux
Mark P. Mattson
SCIENCE SIGNALING (2010)
Drug Development for Alzheimer's Disease: Where Are We Now and Where Are We Headed?
Marwan N. Sabbagh
AMERICAN JOURNAL OF GERIATRIC PHARMACOTHERAPY (2009)
Alzheimer's Disease: From Pathology to Therapeutic Approaches
Roland Jakob-Roetne et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)
Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and β-secretase
Yiping Zhu et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Medicinal Inorganic Chemistry Approaches to Passivation and Removal of Aberrant Metal Ions in Disease
Lauren E. Scott et al.
CHEMICAL REVIEWS (2009)
Amitriptyline is a TrkA and TrkB Receptor Agonist that Promotes TrkA/TrkB Heterodimerization and Has Potent Neurotrophic Activity
Sung-Wuk Jang et al.
CHEMISTRY & BIOLOGY (2009)
Searching for Disease Modifiers-PKC Activation and HDAC Inhibition-A Dual Drug Approach to Alzheimer's Disease that Decreases Aβ Production while Blocking Oxidative Stress
Alan P. Kozikowski et al.
CHEMMEDCHEM (2009)
Tacrine-Melatonin Hybrids as Multifunctional Agents for Alzheimer's Disease, with Cholinergic, Antioxidant, and Neuroprotective Properties
Maria Isabel Fernandez-Bachiller et al.
CHEMMEDCHEM (2009)
Cholinesterase inhibition: is there evidence for disease-modifying effects?
Michael Shanks et al.
CURRENT MEDICAL RESEARCH AND OPINION (2009)
Glycosylated tetrahydrosalens as multifunctional molecules for Alzheimer's therapy
Tim Storr et al.
DALTON TRANSACTIONS (2009)
Brain mitochondria as a primary target in the development of treatment strategies for Alzheimer disease
Gjumrakch Aliev et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)
Novel piperazine derivative PMS1339 exhibits tri-functional properties and cognitive improvement in mice
Jean Marc Miezan Ezoulin et al.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2009)
Pharmacotherapeutic targets in Alzheimer's disease
Yif'at Biran et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2009)
The Crystal Structure of a Complex of Acetylcholinesterase with a Bis-(-)-nor-meptazinol Derivative Reveals Disruption of the Catalytic Triad
Aviv Paz et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Design, Synthesis, and Biological Evaluation of New 5-HT4 Receptor Agonists: Application as Amyloid Cascade Modulators and Potential Therapeutic Utility in Alzheimer's Disease
Olivier Russo et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Site-Activated Multifunctional Chelator with Acetylcholinesterase and Neuroprotective-Neurorestorative Moieties for Alzheimer's Therapy
Hailin Zheng et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Neuroprotective and Cholinergic Properties of Multifunctional Glutamic Acid Derivatives for the Treatment of Alzheimer's Disease
Mariana P. Arce et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Tacripyrines, the First Tacrine-Dihydropyridine Hybrids, as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease
Jose Marco-Contelles et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Toward a Rational Design of Multitarget-Directed Antioxidants: Merging Memoquin and Lipoic Acid Molecular Frameworks
Maria Laura Bolognesi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
The Novel Cholinesterase-Monoamine Oxidase Inhibitor and Antioxidant, Ladostigil, Confers Neuroprotection in Neuroblastoma Cells and Aged Rats
Orit Bar-Am et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2009)
Role of GSK-3β in Adult Brain
Akihiko Takashima
JOURNAL OF PHARMACOLOGICAL SCIENCES (2009)
Design, Selection, and Characterization of Thioflavin-Based Intercalation Compounds with Metal Chelating Properties for Application in Alzheimer's Disease
Cristina Rodriguez-Rodriguez et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Small Molecule Modulators of Copper-Induced Aβ Aggregation
Sarmad S. Hindo et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies
Kurt R. Brunden et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
Natural Antioxidants Protect Neurons in Alzheimer's Disease and Parkinson's Disease
Baolu Zhao
NEUROCHEMICAL RESEARCH (2009)
Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake
Shaomin Li et al.
NEURON (2009)
The Role of Apolipoprotein E in Alzheimer's Disease
Jungsu Kim et al.
NEURON (2009)
Memoquin: A Multi-Target-Directed Ligand as an Innovative Therapeutic Opportunity for Alzheimer's Disease
Maria Laura Bolognesi et al.
NEUROTHERAPEUTICS (2009)
Multiple roles of HDAC inhibition in neurodegenerative conditions
De-Maw Chuang et al.
TRENDS IN NEUROSCIENCES (2009)
Cognitive Function Over Time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT)
ARCHIVES OF NEUROLOGY (2008)
Promising anti-Alzheimer's dimer bis(7)-tacrine reduces β-amyloid generation by directly inhibiting BACE-1 activity
Hongjun Fu et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Current approaches in the treatment of Alzheimer's disease
Reena S. Shah et al.
BIOMEDICINE & PHARMACOTHERAPY (2008)
New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties
Rafael Leon et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling
Scott D. Bembenek et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors
J. N. Cumming et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Potent memapsin 2 (β-secretase) inhibitors:: Design, synthesis, protein-ligand X-ray structure, and in vivo evaluation
Arun K. Ghosh et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds
Lorna Piazzi et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates
Lei Fang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Beta-Secretase: Structure, Function, and Evolution
Chitra Venugopal et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2008)
Mechanism of tau-induced neurodegeneration in Alzheimer disease and related tauopathies
Alejandra del C. Alonso et al.
CURRENT ALZHEIMER RESEARCH (2008)
Metals in Alzheimer's and Parkinson's diseases
Kevin J. Barnham et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2008)
Treatment options in Alzheimer's disease: Maximizing benefit, managing expectations
Martin R. Farlow et al.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2008)
Synthesis of 6-amino-1,4-dihydropyridines that prevent calcium overload and neuronal death
Rafael Leon et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2008)
Targeting multiple Alzheimer's disease etiologies with multimodal neuroprotective and neurorestorative iron chelators
Tamar Amit et al.
FASEB JOURNAL (2008)
Effects of Grape Seed-derived Polyphenols on Amyloid β-Protein Self-assembly and Cytotoxicity
Kenjiro Ono et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1
Nassima Oumata et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Structure-Activity Relationships of Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone. 4. Further Investigation on the Inner Spacer
Vincenzo Tumiatti et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Benzofuran-based hybrid compound's for the inhibition of cholinesterase activity, β amyloid aggregation, and Aβ neurotoxicity
Stefano Rizzo et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation
Pelayo Camps et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Inhibition of acetylcholinesterase, β-amyloid aggregation, and NMDA receptors in Alzheimer's disease:: A promising direction for the multi-target-directed ligands gold rush
Michela Rosini et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-β aggregation
Qiong Xie et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Multi-target-directed ligands to combat neurodegenerative diseases
Andrea Cavalli et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
Dagmar E. Ehrnhoefer et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)
M1 muscarinic Agonists target major hallmarks of Alzheimer's disease the pivotal role of brain M1 receptors
Abraham Fisher
NEURODEGENERATIVE DISEASES (2008)
Preclinical efficacy on GSK-3 inhibitors: Towards a future generation of powerful drugs
Ana Martinez
MEDICINAL RESEARCH REVIEWS (2008)
Linking calcium to Aβ and Alzheimer's disease
Kim N. Green et al.
NEURON (2008)
PPARγ agonists as therapeutics for the treatment of Alzheimer's disease
Gary Landreth et al.
NEUROTHERAPEUTICS (2008)
Inhibition of the cardiac L-type calcium channel current by antidepressant drugs
Ivan Zahradnik et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)
The GSK3 hypothesis of Alzheimer's disease
Claudie Hooper et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Intranasal insulin improves cognition and modulates β-amyloid in early AD
M. A. Reger et al.
NEUROLOGY (2008)
Multi-target-directed drug design strategy: From a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease
Maria Laura Bolognesi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Memantine:: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutarnatergic system -: too little activation is bad, too much is even worse
Chris G. Parsons et al.
NEUROPHARMACOLOGY (2007)
Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Aβ1-42 aggregation for Alzheimer's disease therapeutics
Young Ee Kwon et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2007)
A comparison of the binding profiles of dextromethorphan, memantine, fluoxetine and amitriptyline: Treatment of involuntary emotional expression disorder
Linda L. Werling et al.
EXPERIMENTAL NEUROLOGY (2007)
Extensive SAR and computational studies of 3-{4-[(Benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives
Lorna Piazzi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Redox reactions of copper complexes formed with different β-amyloid peptides and their neuropathalogical relevance
Dianlu Jiang et al.
BIOCHEMISTRY (2007)
The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease
Peter J. Crouch et al.
FEBS JOURNAL (2007)
Purification of CK1 by affinity chromatography on immobilised axin
Jens Reinhardt et al.
PROTEIN EXPRESSION AND PURIFICATION (2007)
Multiwell fluorometric and colorimetric microassays for the evaluation of beta-secretase (BACE-1) inhibitors
Francesca Mancini et al.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2007)
NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: Potential therapeutic role in brain disorders
Rosario Luna-Medina et al.
JOURNAL OF NEUROSCIENCE (2007)
Design and synthesis of novel quinolinone-3-aminoamides and their α-lipoic acid adducts as antioxidant and antiiflammatory agents
Anastasia Detsi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Amitriptyline is a potent blocker of human Kv1.1 and Kv7.2/7.3 channels
Mark A. Punke et al.
ANESTHESIA AND ANALGESIA (2007)
Regulation of Alzheimer's disease amyloid-β formation by casein kinase I
Marc Flajolet et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Design, synthesis, and crystal structure of hydroxyethyl secondary amine-based peptidomimetic inhibitors of human β-secretase
Michel C. Maillard et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
γ-Secretase:: a complex target for Alzheimer's disease
Johan Lundkvist et al.
CURRENT OPINION IN PHARMACOLOGY (2007)
Pharmacological profile of PMS777, a new AChE inhibitor with PAF antagonistic activity
Juan Li et al.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2007)
A small molecule targeting the multifactorial nature of Alzheimer's disease
Andrea Cavalli et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)
VRX-03011, a novel 5-HT4 agonist, enhances memory and hippocampal acetylcholine efflux
Eric G. Mohler et al.
NEUROPHARMACOLOGY (2007)
Novel modulators of amyloid-beta precursor protein processing
Bor Luen Tang et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Combating Alzheimer's disease with multifunctional molecules designed for metal passivation
Harvey Schugar et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)
Lipoic acid as a novel treatment for Alzheimer's disease and related dementias
Lina Holmquist et al.
PHARMACOLOGY & THERAPEUTICS (2007)
Multi-target therapeutics: when the whole is greater than the sum of the parts
Grant R. Zimmermann et al.
DRUG DISCOVERY TODAY (2007)
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
Carlo Ballatore et al.
NATURE REVIEWS NEUROSCIENCE (2007)
Innovation - A robustness-based approach to systems-oriented drug design
Hiroaki Kitano
NATURE REVIEWS DRUG DISCOVERY (2007)
Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease
Jose Marco-Contelles et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
New multipotent tetracyclic tacrines with neuroprotective activity
Jose Marco-Contelles et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine
Nikolay O. Bukanov et al.
NATURE (2006)
Discovery of oxadiazoyl tertiary carbinamine inhibitors of β-secretase (BACE-1)
Hemaka A. Rajapakse et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Opinion - How many drug targets are there?
John P. Overington et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
Synthesis and biological evaluation of new 4H-pyrano[2,3-b]quinoline derivatives that block acetylcholinesterase and cell calcium signals, and cause neuroprotection against calcium overload and free radicals
Jose Marco-Contelles et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2006)
6-Hydroxy- and 6-methoxy-β-carbolines as acetyl- and butyrylcholinesterase inhibitors
Yvonne Schott et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
A century of Alzheimer's disease
Michel Goedert et al.
SCIENCE (2006)
Lipoic acid, a lead structure for multi-target-directed drugs for neurodegeneration
Maria L. Bolognesi et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2006)
Alzheimer 100 - highlights in the history of Alzheimer research
K. A. Jellinger
JOURNAL OF NEURAL TRANSMISSION (2006)
Disease modifying therapy for AD?
Todd E. Golde
JOURNAL OF NEUROCHEMISTRY (2006)
CB1 receptor antagonism increases hippocampal acetylcholine release:: Site and mechanism of action
Aldemar Degroot et al.
MOLECULAR PHARMACOLOGY (2006)
A pro-chelator triggered by hydrogen peroxide inhibits iron-promoted hydroxyl radical formation
Louise K. Charkoudian et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Bis(7)-tacrine attenuates β amyloid-induced neuronal apoptosis by regulating L-type calcium channels
Hongjun Fu et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Platelet-activating factor antagonists protect amyloid-β damaged neurons from microglia-mediated death
Clive Bate et al.
NEUROPHARMACOLOGY (2006)
A practical view of 'druggability'
Thomas H. Keller et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2006)
Strategies for optimizing combinations of molecularly targeted anticancer agents
Janet E. Dancey et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application
MJ Millan
PHARMACOLOGY & THERAPEUTICS (2006)
Three-dimensional models of histamine H3 receptor antagonist complexes and their pharmacophore
FU Axe et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2006)
Chance and necessity in the evolution of minimal metabolic networks
C Pál et al.
NATURE (2006)
Synthesis and reactivity of laquinimod, a quinoline-3-carboxamide:: Intramolecular transfer of the enol proton to a nitrogen atom as a plausible mechanism for ketene formation
K Jansson et al.
JOURNAL OF ORGANIC CHEMISTRY (2006)
Aminoethylenes: A tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1
WJ Yang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties
MI Rodríguez-Franco et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors
Ana Castro et al.
CURRENT PHARMACEUTICAL DESIGN (2006)
A systematic review of the clinical effectiveness of donepezil, rivastigmine and galantamine on cognition, quality of life and adverse events in Alzheimer's disease
A Takeda et al.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2006)
Dimeric and hybrid anti-Alzheimer drug candidates
D Munoz-Torrero et al.
CURRENT MEDICINAL CHEMISTRY (2006)
Development of BACE1 inhibitors for Alzheimer's disease
Tao Guo et al.
CURRENT MEDICINAL CHEMISTRY (2006)
Apolipoprotein (apo) E4 enhances amyloid β peptide production in cultured neuronal cells:: ApoE structure as a potential therapeutic target
SM Ye et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Differential effect of PMS777, a new type of acetylcholinesterase inhibitor, and galanthamine on oxidative injury induced in human neuroblastoma SK-N-SH cells
MJM Ezoulin et al.
NEUROSCIENCE LETTERS (2005)
Nostocarboline:: Isolation and synthesis of a new cholinesterase inhibitor from Nostoc 78-12A
PG Becher et al.
JOURNAL OF NATURAL PRODUCTS (2005)
The evolution of iron chelators for the treatment of iron overload disease and cancer
DS Kalinowski et al.
PHARMACOLOGICAL REVIEWS (2005)
Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer β-amyloid peptide in rodent
NH Greig et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice
K Rezai-Zadeh et al.
JOURNAL OF NEUROSCIENCE (2005)
Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics
S Hanessian et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Regulation of NMDA receptor trafficking by amyloid-β
EM Snyder et al.
NATURE NEUROSCIENCE (2005)
Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron
K Honda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment
LJ Thal et al.
NEUROPSYCHOPHARMACOLOGY (2005)
Melatonin attenuates amyloid beta25-35-induced apoptosis in mouse microglial BV2 cells
MH Jang et al.
NEUROSCIENCE LETTERS (2005)
Novel dimeric acetylcholinesterase inhibitor bis(7)-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors
WM Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation
J Bieschke et al.
BIOCHEMISTRY (2005)
Bioisosteric replacements of the pyrazole moiety of rimonabant:: Synthesis, biological properties, and molecular modeling investigations of thiazoles, triazoles, and imidazoles as potent and selective CB1 cannabinoid receptor antagonists
JHM Lange et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Structural comparisons of meptazinol with opiold analgesics
W Li et al.
ACTA PHARMACOLOGICA SINICA (2005)
Synthesis, acetylcholinesterase inhibition and neuroprotective activity of new tacrine analogues
R León et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2005)
Alzheimer's Disease-Associated Neurotoxic Mechanisms and Neuroprotective Strategies
C. Pereira et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2005)
Rational approach to discover multipotent anti-Alzheimer drugs
M Rosini et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-β aggregation
ML Bolognesi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Multi-functional drugs for various CNS targets in the treatment of neurodegenerative disorders
MBH Youdim et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2005)
Multicomponent therapeutics for networked systems
CT Keith et al.
NATURE REVIEWS DRUG DISCOVERY (2005)
Straightforward access to a structurally diverse set of oxacyclic scaffolds through a four-component reaction
O Jimenez et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)
Antioxidant effect of ferulic acid in isolated membranes and intact cells:: Synergistic interactions with α-tocopherol, β-carotene, and ascorbic acid
S Trombino et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2004)
Synthesis and biological evaluation of new 1,2-dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for treatment of autoimmune disorders:: Structure-activity relationship
S Jönsson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia
BL Roth et al.
NATURE REVIEWS DRUG DISCOVERY (2004)
From large networks to small molecules
JR Sharom et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2004)
Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB1 cannabinoid receptor antagonists
JHM Lange et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
ApoE and clusterin cooperatively suppress Aβ levels and deposition:: Evidence that ApoE regulates extracellular Aβ metabolism in vivo
RB DeMattos et al.
NEURON (2004)
Extending applicability of the oxygen radical absorbance capacity (ORAC-fluorescein) assay
A Dávalos et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2004)
Cholinesterase inhibitors: new roles and therapeutic alternatives
E Giacobini
PHARMACOLOGICAL RESEARCH (2004)
Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease
D Shao et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
ITH4012 (ethyl 5-amino-6,7,8,9-tetrahydro-2-methyl-4-phenylbenzol[1,8]naphthyridine-3-carboxylate), a novel acetylcholinesterase inhibitor with calcium promotor and neuroprotective properties
C Orozco et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
Pathways towards and away from Alzheimer's disease
MP Mattson
NATURE (2004)
Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment
MF Beal
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2004)
From magic bullets to designed multiple ligands
R Morphy et al.
DRUG DISCOVERY TODAY (2004)
A computational study of the binding of propidium to the peripheral anionic site of human acetylcholinesterase
A Cavalli et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Oxidative stress in neurodegeneration: cause or consequence?
JK Andersen
NATURE MEDICINE (2004)
Synthesis, electrochemical and biological studies on polyfunctionalized 4-ferrocenyl-4H-pyran and 4-ferrocenyl-1,4-dihydropyridine derivatives
J Marco-Contelles et al.
TETRAHEDRON LETTERS (2004)
Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast
B Papp et al.
NATURE (2004)
Dissection of amyloid-β precursor protein-dependent transcriptional transactivation
XW Cao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
In situ click chemistry: Enzyme inhibitors made to their own specifications
R Manetsch et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Synthesis, biological evaluation and molecular modelling of diversely functionalized heterocyclic derivatives as inhibitors of acetylcholinesterase/butyrylcholinesterase and modulators of Ca2+ channels and nicotinic receptors
JL Marco et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2004)
Rediscovering the sweet spot in drug discovery
D Brown et al.
DRUG DISCOVERY TODAY (2003)
Apolipoprotein E and β-amyloid (1-42) regulation of glycogen synthase kinase-3β
A Cedazo-Mínguez et al.
JOURNAL OF NEUROCHEMISTRY (2003)
APP processing is regulated by cytoplasmic phosphorylation
MS Lee et al.
JOURNAL OF CELL BIOLOGY (2003)
Neuronal and glial calcium signaling in Alzheimer's disease
MP Mattson et al.
CELL CALCIUM (2003)
SR141716A, a cannabinoid CB1 receptor antagonist, improves memory in a delayed radial maze task
MC Wolff et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2003)
Treatment of Alzheimer's disease: current status and new perspectives
E Scarpini et al.
LANCET NEUROLOGY (2003)
Systematic discovery of multicomponent therapeutics
AA Borisy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
3-(4-{[benzyl(methyl)amino]methyl}-phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation:: A dual function lead for Alzheimer's disease therapy
L Piazzi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression - A randomized controlled trial
PS Aisen et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2003)
Roscovitine and other purines as kinase inhihitors. From starfish oocytes to clinical trials
L Meijer et al.
ACCOUNTS OF CHEMICAL RESEARCH (2003)
GSK-3α regulates production of Alzheimer's disease amyloid-β peptides
CJ Phiel et al.
NATURE (2003)
Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine
T Hikida et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
PR Turner et al.
PROGRESS IN NEUROBIOLOGY (2003)
Design, synthesis and structure-activity relationships of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease
N Toda et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2003)
The specificities of protein kinase inhibitors: an update
J Bain et al.
BIOCHEMICAL JOURNAL (2003)
Prodrugs to enhance central nervous system effects of the TRH-like peptide pGlu-Glu-Pro-NH2
K Prokai-Tatrai et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine
V Tumiatti et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Polymethylene tetraamine backbone as template for the development of biologically active polyamines
C Melchiorre et al.
MEDICINAL RESEARCH REVIEWS (2003)
β-amyloid aggregation induced by human acetylcholinesterase:: inhibition studies
M Bartolini et al.
BIOCHEMICAL PHARMACOLOGY (2003)
Neurobiology of butyrylcholinesterase
S Darvesh et al.
NATURE REVIEWS NEUROSCIENCE (2003)
New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPα
AP Kozikowski et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Acetylcholinesterase complexed with bivalent ligands related to huperzine A: Experimental evidence for species-dependent protein-ligand complementarity
DM Wong et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site
Y Bourne et al.
EMBO JOURNAL (2003)
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors
L Savini et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting A beta amyloid deposition and toxicity in Alzheimer disease - A pilot phase 2 clinical trial
CW Ritchie et al.
ARCHIVES OF NEUROLOGY (2003)
Cannabinoids and Memory: Animal Studies
Claudio Castellano et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2003)
Fast anterograde transport of Herpes Simplex Virus: Role for the amyloid precursor protein of Alzheimer's disease
P Satpute-Krishnan et al.
AGING CELL (2003)
Histamine H-3 Receptor: A Potential Drug Target for the Treatment of Central Nervous System Disorders
L. F. Alguacil et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2003)
Comparative efficacy between venlafaxine and SSRIs: A pooled analysis of patients with depression
SM Stahl et al.
BIOLOGICAL PSYCHIATRY (2002)
An iron-responsive element type II in the 5′-untranslated region of the Alzheimer's amyloid precursor protein transcript
JT Rogers et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter targeting potential agents for Alzheimer's disease
H Kogen et al.
ORGANIC LETTERS (2002)
Role of Dbl's big sister in the anti-mitogenic pathway from α1B-adrenergic receptor to c-Jun N-terminal kinase
J Yamauchi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
SL65.0155, a novel 5-hydroxytryptamine4 receptor partial agonist with potent cognition-enhancing properties
PC Moser et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
AF150(S) and AF267B - M1 muscarinic agonists as innovative therapies for Alzheimer's disease
A Fisher et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2002)
Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
J Hardy et al.
SCIENCE (2002)
Novel tacrine derivatives that block neuronal calcium channels
C de los Ríos et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2002)
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
DM Walsh et al.
NATURE (2002)
Human and murine ApoE markedly alters Aβ metabolism before and after plaque formation in a mouse model of Alzheimer's disease
AM Fagan et al.
NEUROBIOLOGY OF DISEASE (2002)
Synthesis and antinephritic activities of quinoline-3-carboxamides and related compounds
K Tsuji et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2002)
Activation of peroxisome proliferator-activated receptor isoforms and inhibition of prostaglandin H2 synthases by ibuprofen, naproxen, and indomethacin
MS Jaradat et al.
BIOCHEMICAL PHARMACOLOGY (2001)
Evidence of oxidative damage in Alzheimer's disease brain:: central role for amyloid β-peptide
DA Butterfield et al.
TRENDS IN MOLECULAR MEDICINE (2001)
Acetylcholinesterase inhibitors:: SAR and kinetic studies on ω-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl derivatives
A Rampa et al.
JOURNAL OF MEDICINAL CHEMISTRY (2001)
A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
S Weggen et al.
NATURE (2001)
The multifaceted roles of glycogen synthase kinase 3β in cellular signaling
CA Grimes et al.
PROGRESS IN NEUROBIOLOGY (2001)
Calcium entry through L-type calcium channels causes mitochondrial disruption and chromaffin cell death
MF Cano-Abad et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Dysregulation of cellular calcium homeostasis in Alzheimer's disease - Bad genes and bad habits
MP Mattson et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2001)
A structural motif of acetylcholinesterase that promotes amyloid β-peptide fibril formation
GV De Ferrari et al.
BIOCHEMISTRY (2001)
Neurodegenerative changes associated with β-amyloid deposition in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes
MA Kurt et al.
EXPERIMENTAL NEUROLOGY (2001)
Thioflavin T is a fluorescent probe of the acetylcholinesterase peripheral site that reveals conformational interactions between the peripheral and acylation sites
GV De Ferrari et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Alzheimer's disease amyloid-β binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits
CC Curtain et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Protection against β-amyloid peptide toxicity in vivo with long-term administration of ferulic acid
JJ Yan et al.
BRITISH JOURNAL OF PHARMACOLOGY (2001)
Synthesis and acetylcholinesterase/butyrylcholinesterase inhibition activity of new tacrine-like analogues
JL Marco et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2001)
Cell biology - Principles for the buffering of genetic variation
JL Hartman et al.
SCIENCE (2001)
Characterization of copper interactions with Alzheimer amyloid β peptides:: Identification of an attomolar-affinity copper binding site on amyloid β1-42
CS Atwood et al.
JOURNAL OF NEUROCHEMISTRY (2000)
Radical scavenger activity of phenylethanoid glycosides in FMLP stimulated human polymorphonuclear leukocytes:: Structure-activity relationships
J Heilmann et al.
PLANTA MEDICA (2000)
Galantamine - A review of its use in Alzheimer's disease
LJ Scott et al.
DRUGS (2000)
Central nicotinic receptors, neurotrophic factors and neuroprotection
N Belluardo et al.
BEHAVIOURAL BRAIN RESEARCH (2000)
Potent acetylcholinesterase inhibitors: Design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts
C Guillou et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2000)
Bis(7)-tacrine, a novel acetylcholinesterase inhibitor, reverses AF64A-induced deficits in navigational memory in rats
J Liu et al.
NEUROSCIENCE LETTERS (2000)
Lessons learned from the development of an Abl tyrosine kinase inhibitor for chronic myelogenous leukemia
BJ Druker et al.
JOURNAL OF CLINICAL INVESTIGATION (2000)
Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: comparison with tacrine
XQ Xiao et al.
NEUROSCIENCE LETTERS (2000)
Low affinity channel blocking (uncompetitive) NMDA receptor antagonists as therapeutic agents - toward an understanding of their favorable tolerability
MA Rogawski
AMINO ACIDS (2000)
分享论文
