期刊
MEDICINAL RESEARCH REVIEWS
卷 30, 期 2, 页码 327-393出版社
WILEY
DOI: 10.1002/med.20196
关键词
shiga; glycan; recognition; influenza; protein-glycan specificity
资金
- NSF [CAREER CHE-0845005]
- UC Nanotechnology Institute
- NIAID [U01-A1075498]
Glycans decorate over 95% of the mammalian cell surface in the form of glycolipids and glycoproteins. Several toxins and pathogens bind to these glycans to enter the cells. Understanding the fundamentals of the complex interplay between microbial pathogens and their glycan receptors at the molecular level could lead to the development of novel therapeutics and diagnostics. Using Shiga toxin and influenza virus as examples, we describe the complex biological interface between host glycans and these infectious agents, and recent strategies to develop glycan-based high-affinity ligands. These molecules are expected to ultimately be incorporated into diagnostics and therapeutics, and can be used as probes to Study important biological processes. Additionally, by focusing on the specific glycans that microbial pathogens target, we can begin to decipher the glycocode and how these glycans participate in normal and aberrant cellular communication. (C) 2010 Wiley Periodicals, Inc. Med Res Rev, 30, No. 2. 327-393, 2010
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据