期刊
MEDICINAL RESEARCH REVIEWS
卷 32, 期 5, 页码 999-1025出版社
WILEY
DOI: 10.1002/med.20231
关键词
gelsolin; actin; apoptosis; cancer; cardiac remodeling
资金
- Canada Research Chair (Tier 1)
- Heart and Stroke Foundation [NA6736]
Gelsolin, a Ca2+-regulated actin filament severing, capping, and nucleating protein, is an ubiquitous, multifunctional regulator of cell structure and metabolism. More recent data show that gelsolin can act as a transcriptional cofactor in signal transduction and its own expression and function can be influenced by epigenetic changes. Here, we review the functions of the plasma and cytoplasmic forms of gelsolin, and their manifold impacts on cancer, apoptosis, infection and inflammation, cardiac injury, pulmonary diseases, and aging. An improved understanding of the functions and regulatory mechanisms of gelsolin may lead to new considerations of this protein as a potential biomarker and/or therapeutic target.
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