期刊
MEDICINAL RESEARCH REVIEWS
卷 30, 期 3, 页码 419-462出版社
WILEY
DOI: 10.1002/med.20164
关键词
protein kinase CK2
资金
- PROKINASERESEARCH [503457]
- European Commission [503467]
CK2 is a pleiotropic, ubiquitous, and constitutively active protein kinase (PK), with both cytosolic and nuclear localization in most mammalian cells. The holoenzyme is generally composed of two catalytic (alpha and/or alpha') and two regulatory (beta) subunits, but the free alpha/alpha' subunits are catalytically active by themselves and can be present in cells under some circumstances. CK2 catalyzes the phosphorylation of more than 300 substrates characterized by multiple acidic residues surrounding the phosphor-acceptor amino acid, and, consequently, it plays a key role in several physiological and pathological processes. But how can one kinase orchestrate all these tasks faithfully? How is it possible that one kinase can, despite all pleiotropic characteristics of PKs in general, be involved in so many different biochemical events? Is CK2 a druggable target? Several questions are still to be clearly answered, and this review is an occasion for a fruitful discussion. (C) 2009 Wiley Periodicals, Inc. Med Res Rev, 30, No. 3, 419-462, 2010
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