Triarylimidazoles-synthesis of 3-(4,5-diaryl-1H-imidazol-2-yl)-2-phenyl-1H-indole derivatives as potent α-glucosidase inhibitors

A series of new trisubstituted imidazoles-3-(4,5-diaryl-1H-imidazol-2-yl)-2-phenyl-1H-indole derivatives (2a-2u) were synthesized and evaluated for their alpha-glucosidase inhibition. The new compounds showed significant alpha-glucosidase inhibitory activity as compared to the standard inhibitor acrabose. Structures of synthesized compounds were determined using FT-IR, Mass spectrometry, H-1 NMR, C-13 NMR, and elemental analyses.