Synthesis and anti-inflammatory evaluation of new pyrazoles bearing biodynamic thiazole and thiazolidinone scaffolds

New trisubstituted pyrazoles bearing thiazolyl and thiazolidinonyl moieties have been successfully and conveniently synthesized in three steps using 5-acetyl thiazoles (1a-b) as starting materials. The route includes the synthesis of new intermediates, 4-formyl 5-thiazolyl pyrazoles (4a-b). The formyl pyrazoles on one pot cyclocondensation with anilines and thioglycolic acid have been found to yield the titled compounds (7a-j). The new pyrazoles have been screened to evaluate in vivo anti-inflammatory activity and compounds 7c, 7d, 7f, 7g, 7h, and 7i have better anti-inflammatory activity than reference drug Celecoxib. The synthetic details and results of anti-inflammatory activity are discussed.