期刊
MEDICINAL CHEMISTRY RESEARCH
卷 23, 期 2, 页码 1031-1036出版社
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-013-0706-1
关键词
Polyhydroquinoline; Four-component coupling; Polyethylene glycol; Catalyst-free conversion; Cytotoxicity
资金
- CSIR
- UGC, New Delhi
An eco-friendly one-pot synthesis of polyhydroquinolines by four-component coupling of aldehydes, dimedone, ethylacetoacetate, and ammonium acetate using polyethylene glycol as a solvent at room temperature has been accomplished. The conversion was complete within 2-4 h, and the products were formed in high yields (83-95 %). No any additional catalyst was required. Several known and unknown polyhydroquinolines have been prepared. Some of the compounds exhibited impressive cytotoxic activity.
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