Synthesis of halogenated derivatives of thymol and their antimicrobial activities

In order to test the antibacterial and antifungal activities of different halogenated thymol derivatives, thymol has been converted into chlorothymol, dichlorothymol with N-chlorosuccinimide; monobromothymol, dibromothymol with N-bromosuccinimide; O-methylated iodothymol with ceric ammonium nitrate and iodine from methylated thymol. Among the different derivatives tested, 4-chlorothymol was found to be most active against Staphylococcus aureus and Staphylococcus epidermis at a concentration of 12.5 and 25 ppm, respectively. Also it was tested to be active against Candida albicans (AI).