期刊
MEDICINAL CHEMISTRY RESEARCH
卷 21, 期 11, 页码 3327-3335出版社
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-011-9846-3
关键词
Phosphodiesterase 4 (PDE4) inhibitors; Quinazolinone; Asthma; Synthesis
In this study, a novel series of quinazolinone derivatives analogue to nitraquazone structure were synthesized. The compounds tested for their inhibitory activity against phosphodiesterase 4B revealed that compound 6d shows promising inhibitory activity comparable to that of Rolipram, whereas compounds 6a and 6c exhibited moderate inhibitory activity.
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