期刊
MEDICINAL CHEMISTRY RESEARCH
卷 21, 期 11, 页码 3692-3698出版社
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-011-9922-8
关键词
Tetrazole; Quinoline; Forced swimming test; Tail suspension test
资金
- Doctor Research Start Foundation of Heilongjiang Bayi Agriculture University
- Project of Animal Good farming Innovation Team of Heilongjiang Higher Education Committee [SCX2011-10]
In this study, a novel series of 4,5-dihydro-7-alkoxy(phenoxy)-tetrazolo[1,5-a]quinoline derivatives was synthesized as potential antidepressant agents. Their antidepressant activities were evaluated by the forced swimming test and tail suspension test models. The pharmacological results showed that 7-(4-fluorobenzyloxy)-4,5-dihydrotetrazolo[1,5-a]quinoline 7j was found possessing strong activity in the both tests, especially in the FTS model, which was considered as the most promising compounds in this study.
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