期刊
MEDICINAL CHEMISTRY RESEARCH
卷 20, 期 4, 页码 522-530出版社
BIRKHAUSER BOSTON INC
DOI: 10.1007/s00044-010-9326-1
关键词
Coumarin derivatives; Crystal structure; Chalcone
资金
- Tunisian Ministry of Higher Education and Scientific Research and Technology
- Spanish Agency of International Cooperation [A/9549/07, A/8302/07]
A series of new coumarin derivatives 4 containing a chalcone moiety were synthesized by condensation of 3-acetyl-4-hydroxycoumarin 1 with aryl or heteroaryl aldehydes 2 in the presence of piperidine in chloroform. The interaction of 3-formyl-4-chloro-coumarin 3 with nitrogen compound nucleophiles are described and lead to the corresponding substituted chromen[4,3-c] pyrazol-4-ones 5. The structures of the obtained compounds were established on the basis of IR|1D|2D NMR, while crystal structure of 3-acetyl-4-hydroxy coumarin 1 was determined using X-ray diffraction and further were evaluated for possible antibacterial and antioxidant activities. The coumarinic chalcone 4d has been found to be the most active (IC(50) = 2.07 mu M) in this study.
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