期刊
MEDICINAL CHEMISTRY RESEARCH
卷 21, 期 1, 页码 27-37出版社
BIRKHAUSER BOSTON INC
DOI: 10.1007/s00044-010-9489-9
关键词
Pyridine; Nicotine; Epibatidine; Mecamylamine; Analgesic activity
资金
- University of Pune
A series of new heterocyclic derivatives having a pyridine nucleus were synthesized. 4-(5-(2-Chlorophenyl)-4H-1,2,4-triazol-3-yl)pyridine (7c) and 4-(5-(2-Nitrophenyl)-4H-1,2,4-triazol-3-yl)pyridine (7d) presented the best analgesic profie of this series in hot-plate, tail-flick, and formalin-induced licking tests, which was partially prevented by pretreatment with mecamylamine, a nicotinic receptor antagonist.
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