期刊
MEDICINAL CHEMISTRY RESEARCH
卷 19, 期 3, 页码 236-249出版社
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-009-9187-7
关键词
Thioxothiazolidin-4-one; EAT cells; Lifespan; Anticancer; Antiangiogenesis
资金
- UGC, Govt. of India [31-143/2005]
- UGC-SAP [540/10/2004-05]
- CSIR, New Delhi
- CSIR SRF [09/119(0172)2K8 EMR-I]
- DST-FIST [SR/FST/CSI-051/2002]
A series of novel thioxothiazolidin-4-one derivatives 5(a-g) were synthesized by the coupling of different amines containing aliphatic, substituted aromatic, and heterocyclic moieties, such as oxadiazol, pyrazole, isoxazole, and piperazine with 2-(5-(4-chlorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid. All compounds were characterized by H-1 NMR, LCMS, FTIR and elemental analysis. In this study, we investigated the possibility that these novel thioxothiazolidin-4-one derivatives 5(a-g) inhibits tumor growth and tumor induced angiogenesis using mouse Ehrlich Ascites Tumor (EAT) as a model system. Our results demonstrated that the compounds significantly reduced ascites tumor volume, cell number, and increased the life span of EAT-bearing mice. In addition, the compounds manifested strong antiangiogenic effects and suppressed tumor induced endothelial proliferation in the mice peritoneum. From our findings, it is noted that the derivatives 5(a-e) may be possible candidates for anticancer therapy with the ability to inhibit tumor angiogenesis and tumor cell proliferation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据