期刊
MEDICINAL CHEMISTRY
卷 8, 期 3, 页码 415-420出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1573406411208030415
关键词
Kaempferol-3-O-rutinoside; Osyris wightiana Wall. ex Wight; antiglycation activity; cytotoxicity; Diabetes
Kaempferol-3-O-alpha-L-rhamanopyranosyl-(1'-6 '')-beta-D-glucopyranoside (1) (Nicotiflorin or kaempferol-3-O-rutinoside), isolated from the aerial parts of Osyris wightiana Wall. ex Wight, has exhibited a potent antiglycation activity in vitro. A short and efficient route to kaempferol-3-O-rutinoside (1) is also described in this paper. To study the Structure-Activity Relationship (SAR), few other derivatives of kaempferol were also evaluated for their antiglycation activity. Moreover the cytotoxicity analysis was also performed for these compounds prepared and SAR studies showed that sugar derivatives of kaempferol possess a promising antiglycation activity.
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