Germatranyl Substituted Organotin (IV) Carboxylates: Synthesis Spectroscopic Characterization and Biological Activities

Eight new organotin (IV) derivatives of general formula [N(CH2CH2O)(3)GeCH(R-1)CH2COO](4-n)SnRn2, where n = 2, R-2 = C2H5 (1-5); R-1 = CH3 (1); C6H5 (2); p-CH3C6H4 (3); p-FC6H4(4); p-CH3OC6H4 (5) and n = 3, R-2 = CH2C6H5 (6-8), R-1 = CH3 (6); C6H5 (7); p-CH3C6H4 (8) have been synthesized by the reaction of di- or tri-organotin chloride with the corresponding germatranyl (substituted) propionic acid in the appropriate mole ratios using triethylamine as a base. The synthesized compounds were characterized by various spectroscopic techniques such as IR, multi-nuclear (H-1, C-13, Sn-119) NMR, (119)m Sn Mossbauer, along with elemental analyses. They were also screened for in vitro anti-leishmanial activity against promastigotes of leishmania donovani and found some encouraging results.