期刊
MEDICINA CLINICA
卷 137, 期 12, 页码 533-540出版社
ELSEVIER ESPANA SLU
DOI: 10.1016/j.medcli.2010.11.032
关键词
Tumor necrosis factor antagonists; Infection; Etiology; Prognosis; Rheumatic diseases
资金
- Sociedad Espanola de Reumatologia
- Agencia Espanola de Medicamentos y Productos Sanitarios
- Schering-Plough
- Wyeth
- Abbott Immunology
- Roche Farma
- Bristol-Myers Squibb, Spain
- Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III, Red Espanola de Investigacion en Enfermedad Infecciosa [REIPI RD06/0008]
- Schering
- Roche
- Abbott Laboratories
- Bristol Meyers Squibb
Background and objectives: Whether the use of tumor necrosis factor antagonists increases the risk of infection remains a subject of open debate. Developing effective strategies of prevention and empirical treatment entails carefully establishing the etiology and prognosis of the infections. Patients and methods: Analysis of the Spanish registry BIOBADASER (Feb-2000 to Jan-2006), a national drug safety registry of patients with rheumatic diseases. Results: 907 episodes of infection occurring in 6,969 patients were analyzed. The infection incidence observed was 53.09 cases/1,000 patients-years (Cl 95% 49.69-56.66). The most frequent infections were skin infect ion (12.18 cases/1,000 patients-yrs), pneumonia (5.97 cases/1,000 patients-yrs), cystitis (3.92 cases/1,000 patients-yrs), tuberculosis (3.51 cases/1,000 patients-yrs) and arthritis (3.76 cases/1,000 patients-yrs). Staphylococcus aureus, Staphylococcus epidennidis, Escherichia coli, Pseudomonas aeruginosa and Salmonella spp. emerged as important pathogens. Varicella zoster virus and Herpes simplex virus caused most cases of viral infections. Mucocutaneous candidiasis accounted for most fungal infections. Mortality was increased in infected patients (log-rank test p < 0.0001). Pneumonia, sepsis, tuberculosis, abdominal infection and endocarditis were associated with significant attributable mortality. Conclusions: A significant number of bacterial, viral and fungal infections occurred in patients with rheumatic diseases treated with TNF antagonists. The information of this study can illuminate clinicians globally on how to address infection in this vulnerable group of patients. (C) 2010 Elsevier Espana, S.L. All rights reserved.
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