期刊
RNA BIOLOGY
卷 12, 期 10, 页码 1094-1098出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15476286.2015.1063770
关键词
chromatin modification; chromatin remodeling; human diseases; lncRNA promoter; lncRNA regulation; long non-coding RNA; RNA therapeutics
资金
- NHLBI NIH HHS [R01 HL121197, R01 HL118087, HL118087, HL085345, HL121197] Funding Source: Medline
Long noncoding RNAs (lncRNAs) are pivotal regulators of genome structure and gene expression. LncRNAs can directly interact with chromatin-modifying enzymes and nucleosome-remodeling factors to control chromatin structure and accessibility of genetic information. Moreover, lncRNA expression can be controlled by chromatin-remodeling factors, suggesting a feedback circuit of regulation. Here, we discuss the recent advances of lncRNA studies, focusing on the function and mechanism of lncRNA-chromatin interactions.
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