期刊
MEDICAL PHYSICS
卷 37, 期 8, 页码 4475-4484出版社
WILEY
DOI: 10.1118/1.3466831
关键词
EEG source analysis; spherical and realistic head model; skull conductivity perturbation; forward-inverse problem
资金
- MEDISIP
- FWO-Vlaanderen, Flanders, Belgium
Purpose: Electroencephalogram (EEG) source analysis is a noninvasive technique used in the presurgical of epilepsy. In this study, the dipole location and orientation errors due to skull conductivity perturbations were investigated in two groups of three-dimensional head models: A spherical head model and a realistic head model. Methods: In each group, the head model had a brain-to-skull conductivity ratio (R-sigma) within the range of 10-40. Solving the forward problem in the head model with skull conductivity perturbations along with the inverse problem in the baseline head model with R-sigma=20 permitted the derivation of the dipole estimation errors. Results: Perturbations in the skull conductivity generated dipole location and orientation errors: The larger the perturbations, the larger the errors and the error ranges. The dipole orientation error due to skull conductivity perturbations was not great (maximal mean of <5 degrees) in this study, but the dipole location error was notable (maximal mean of >5 mm). Conclusions: Therefore, the influence of skull conductivity perturbations on EEG dipole source analysis cannot be neglected. This study suggests that it is necessary to measure the skull conductivity of the individual patients in order to achieve accurate EEG source analysis. (C) 2010 American Association of Physicists in Medicine. [DOI: 10.1118/1.3466831]
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