期刊
RHEUMATOLOGY
卷 55, 期 1, 页码 16-24出版社
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/kev270
关键词
osteoarthritis; cholesterol; low density lipoproteins; oxidized low density lipoproteins; metabolic syndrome; synovium; inflammation; macrophages; joint pathology; statins
类别
资金
- ReumaFonds [LLP-7] Funding Source: researchfish
There is increasing evidence that low-density lipoprotein (LDL) cholesterol plays a role in the pathology of OA. Specifically, oxidized LDL (oxLDL), which has been shown to play an essential role during development of atherosclerosis, could be involved in processes such as synovial inflammation, cartilage destruction and bone deformations. OxLDL can activate synovial cells such as macrophages, endothelial cells and synovial fibroblasts, resulting in release of growth factors, MMP and pro-inflammatory cytokines. In this review article, we discuss the role of LDL and oxLDL in OA joint pathology and share our viewpoint of possible mechanisms by which these proteins could influence the development and progression of OA. The proposed theory could provide insight into the aetiopathology of OA and give rise to new potential treatments.
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