期刊
MEDICAL PHYSICS
卷 35, 期 4, 页码 1170-1179出版社
WILEY
DOI: 10.1118/1.2868778
关键词
x-ray; micro-CT; small animal; cardiac; image reconstruction; 4D CT; low dose
资金
- NCI NIH HHS [U24 CA092656, R21 CA124584-02, R21 CA124584-01, 5R21 CA114680, R21 CA114680, R21 CA114680-02, U24 CA092656-08, R21 CA124584] Funding Source: Medline
- NCRR NIH HHS [P41 RR005959, P41 RR005959-18] Funding Source: Medline
Recent advances in murine cardiac studies with three-dimensional cone beam micro-computed tomography (CT) have used either prospective or retrospective gating technique. While prospective gating ensures the best image quality and the highest resolution, it involves longer sampling times and higher radiation dose. Sampling is faster and the radiation dose can be reduced with retrospective gating but the image quality is affected by the limited number of projections with an irregular angular distribution which complicate the reconstruction process, causing significant streaking artifacts. This work involves both prospective and retrospective gating in sampling. Deformable registration is used between a high quality image set acquired with prospective gating with the multiple data sets during the cardiac cycle obtained using retrospective gating. Tests were conducted on a four-dimensional (4D) cardiac mouse phantom and after optimization, the method was applied to in vivo cardiac micro-CT data. Results indicate that, by using our method, the sampling time can be reduced by a factor of 2.5 and the radiation dose can be reduced 35% compared to the prospective sampling while the image quality can be maintained. In conclusion, we proposed a novel solution to 4D cine cardiac micro-CT based on a combined prospective with retrospective gating in sampling and deformable registration post reconstruction that mixed the advantages of both strategies. (C) 2008 American Association of Physicists in Medicine.
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