期刊
MEDICAL ONCOLOGY
卷 32, 期 1, 页码 -出版社
HUMANA PRESS INC
DOI: 10.1007/s12032-014-0391-z
关键词
Fatty acid synthase; HER2; Ovarian cancer; Clinicopathological factors
类别
资金
- National Natural Science Foundation of China [30973475]
- Natural Science Foundation of JiangSu Province [BK2012749]
- Maternal and Jiangsu Provincial Maternal and child health research project of JiangSu Health Department [F201351]
The present study was designed to explore the cross talk between fatty acid synthase (FASN) and HER2 (ErbB2) in ovarian cancer. A total of 60 ovarian cancer patients and 15 normal ovarian tissues were enrolled. Tissue array was conducted by using a tissue microarray instrument. Immunohistochemistry was performed to quantify the expressions of HER2 and FASN. The FASN was detected to be distributed in the cell cytoplasm and was significantly correlated with cancer grade (p = 0.000) and FIGO staging (p = 0.000). Patients with FASN overexpression in ovarian cancer tend to have a worse overall survival rate (p = 0.000). HER2 was also stained to be distributed in the cell cytoplasm associated with higher expression in high-grade cancer. It was also disclosed that FASN expression level is not correlated with HER2 status in ovarian cancer. These results for the first time indicated that a cross talk in FASN and HER2 expressions might be associated with prognosis in malignant ovarian cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据