期刊
MEDICAL ONCOLOGY
卷 31, 期 1, 页码 -出版社
HUMANA PRESS INC
DOI: 10.1007/s12032-013-0774-6
关键词
Haematopoietic growth factor; Granulocyte-macrophage colony-stimulating factor; Innate immunity; Adaptive immunity
类别
资金
- National Council for Science and Technology (CONACYT), Mexico
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is often used to treat leucopenia. Other haematopoietins may increase the number of circulating leucocytes with higher efficiency, but GM-CSF has additional effects that may be far more relevant than its haematopoietic activity. GM-CSF induces differentiation, proliferation and activation of macrophages and dendritic cells which are necessary for the subsequent T helper cell type 1 and cytotoxic T lymphocyte activation. GM-CSF haematopoietic and non-haematopoietic functions have pro-inflammatory and immune regulatory potential to treat a variety of autoimmune diseases and tumours. On the other hand, GM-CSF deficiency leads to various immune dysfunctions and the current utilization of GM-CSF as haematopoietic factor might be an accurate but very incomplete indication for a cytokine with vast clinical potential.
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