期刊
MEDICAL ONCOLOGY
卷 30, 期 1, 页码 -出版社
HUMANA PRESS INC
DOI: 10.1007/s12032-012-0414-6
关键词
Lung cancer; Single-nucleotide polymorphism; Inflammation; Interleukin 6
类别
资金
- scientific and technological breakthroughs project (Shenyang City, P. R. China) [1091149-9-00]
- science and technology project (Liaoning Province, P. R. China) [2011225019]
This study was to investigate the association of inflammation-related factors with the risk of lung cancer. All subjects were unrelated ethnic Han Chinese in Liaoning province. Our study conducted a hospital-based case-control study, the case group consisted of 193 histologically diagnosed lung cancer patients, and 211 controls were selected from cancer-free patients at the same. 5 single-nucleotide polymorphisms (TGF beta 1 +869T/C, IL6 -634C/G, TGF beta 1 -509C/T, IL1 beta -511C/T, and IL1 alpha -899C/T) in inflammatory genes (IL1, IL6, TGF) were analyzed by Taqman real-time PCR method. All statistical analyses were performed with statistical product and service solutions v13.0. The genotype distribution frequency of IL6 -634C/G exists significant difference between case and control group. Individuals carrying -634GG and CG genotype had a higher risk of lung cancer. The risk allele was G in IL6 -634C/G.
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