期刊
MEDICAL ONCOLOGY
卷 27, 期 -, 页码 7-13出版社
HUMANA PRESS INC
DOI: 10.1007/s12032-010-9527-y
关键词
Immunomodulatory agents; Bone marrow microenvironment; Multiple myeloma
类别
资金
- Department of Veterans Affairs
- NIH [RO1-124929, P50-100707, PO1-78378]
Immunomodulatory agents (IMiD's) have become an important drug category in the treatment of multiple myeloma. The agents have a complex mechanism of action that influence the microenvironment in the bone marrow. The microenvironment is an essential promotor of disease progression and therefore important in targeting the disease. The article reviews mechanism of action and essential pathways of IMiD's that are important in disease treatment.
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