期刊
MEDICAL ONCOLOGY
卷 27, 期 4, 页码 1114-1118出版社
HUMANA PRESS INC
DOI: 10.1007/s12032-009-9344-3
关键词
Curcumin; miR-15a; miR-16; Breast cancer; Bcl-2
类别
资金
- National Natural Science Foundation of China [30872400]
The medicinal properties of curcumin are well documented in Indian and Chinese systems of medicine, which refer to its wide use in the treatment of some diseases. It has shown to have anti-carcinogenic properties and is known to prevent tumor development in some cancers. In our study, we confirmed that the expression of miR-15a and miR-16 was upregulated and that of Bcl-2 was downregulated in curcumin-treated MCF-7 cells. Silencing miR-15a and miR-16 by specific inhibitors restored the expression of Bcl-2. Thus, we concluded that curcumin can reduce the expression of Bcl-2 by upregulating the expression of miR-15a and miR-16 in MCF-7 cells.
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