期刊
MEDICAL MYCOLOGY
卷 52, 期 6, 页码 555-564出版社
OXFORD UNIV PRESS
DOI: 10.1093/mmy/myu029
关键词
systemic candidiasis; innate immunity; neutrophils; monocytes/macrophages
资金
- Division of Intramural Research of the National Institute of Allergy and Infectious Diseases, National Institutes of Health
Systemic infection caused by Candida species is the fourth leading cause of nosocomial bloodstream infection in modern hospitals and carries high morbidity and mortality despite antifungal therapy. A recent surge of immunological studies in the mouse models of systemic candidiasis and the parallel discovery and phenotypic characterization of inherited genetic disorders in antifungal immune factors that are associated with enhanced susceptibility or resistance to the infection have provided new insights into the cellular and molecular basis of protective innate immune responses against Candida. In this review, the new developments in our understanding of how the mammalian immune system responds to systemic Candida challenge are synthesized and important future research directions are highlighted.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据