期刊
MEDICAL MYCOLOGY
卷 47, 期 3, 页码 227-236出版社
OXFORD UNIV PRESS
DOI: 10.1080/13693780802209082
关键词
innate immunity; escape mechanisms; Toll-like receptor
资金
- Health Manpower Development Plan (HMDP) Fellowship
- Ministry of Health, Singapore
- Agency for Science, Technology and Research (A* STAR), Singapore
A successful pathogen is one that is able to effectively survive and evade detection by the host innate immune defense. Fungal pathogens have adopted strategies which evade host defense and eventually cause disease in at-risk patients. Shielding of stimulatory surface recognition molecules, shedding of decoy components, induction of anti-inflammatory signals, complement evasion and resilient survival capacity are successful evasion mechanisms employed by fungal pathogens. Understanding these complex pathways of immune evasion can potentially contribute to development of novel therapeutic strategies against fungal infections.
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