期刊
MEDICAL MYCOLOGY
卷 47, 期 -, 页码 S331-S337出版社
OXFORD UNIV PRESS
DOI: 10.1080/13693780802266777
关键词
Aspergillus; cystic fibrosis; allergy
资金
- National Institutes of Health [P50HL084932]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P50HL084932] Funding Source: NIH RePORTER
Allergic bronchopulmonary aspergillosis (ABPA) is an allergic disease characterized clinically by wheezing, pulmonary infiltrates, bronchiectasis, and fibrosis that affects patients with asthma and cystic fibrosis (CF). Although this disease has been characterized by a Th2 immune response to Aspergillus, the disease has some features such as central bronchiectasis which is not seen in other Th2 driven lung diseases such as atopic asthma. Here we will review the current pathophysiology of ABPA in CF and highlight new molecules that may affect immune responses against Aspergillus and ABPA disease pathogenesis.
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