期刊
MEDICAL MOLECULAR MORPHOLOGY
卷 45, 期 1, 页码 29-34出版社
SPRINGER JAPAN KK
DOI: 10.1007/s00795-011-0538-3
关键词
Immunoglobulin A nephropathy; Electron microscopy; Paramesangial deposit; Subepithelial deposit; Subendothelial deposit; Intramembranous deposit
资金
- Grants-in-Aid for Scientific Research [24591214] Funding Source: KAKEN
Immunoglobulin A nephropathy (IgAN) is characterized by mesangial cell proliferation and mesangial expansion with mesangial depositions of IgA. We have found that electron-dense deposits (EDD) are often observed in areas other than paramesangial areas in glomeruli. To compare electron microscopic findings with light microscopic findings and clinical data, we examined the biopsies from 178 patients with IgAN. Patients were divided into two groups: group A had only paramesangial deposits and group B had deposits not only in paramesangial areas but also in other areas. All patients examined in this study had EDD in glomerular paramesangial areas. Thirty-six patients were included in group B. Cellular crescent formation in glomeruli and urinary protein in group B were significantly higher than those in group A (P < 0.01). Serum albumin and estimated glomerular filtration rate (eGFR) in group B were significantly lower than those in group A (P < 0.05). Group B showed a significant positive correlation with histological severity, which is defined in the Japanese Clinical Guidelines on IgAN. In patients with broad distribution of EDD, urinary protein was significantly increased (P < 0.05). Detailed observation of EDD distribution has an impact on evaluation of the disease activity of IgAN.
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