期刊
MEDICAL HYPOTHESES
卷 119, 期 -, 页码 37-40出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.mehy.2018.07.024
关键词
-
资金
- National Natural Science Foundation of China [81741143]
- Education Department of Hunan Province, China [17A186]
- Natural Science Foundation of Hunan Province, China [2018JJ3458]
Radiation-induced enteritis is one of the most common complications in patients under radiotherapy at abdominal or pelvic cavity. Up to 50% of patients treated with pelvic radiotherapy has been reported radiation-induced acute enteritis, and half of them developed chronic enteritis. Overproduction of free radicals, activation of inflammatory pathways and vascular endothelial dysfunction were considered as the primary mechanisms of radiation-induced enteritis. Because probiotics have been demonstrated as a promising potential candidate for treating intestinal diseases, it may be a safer and more effective radioprotector for the enteritis compared to conventional chemical agents with inherent toxicities. Here, we propose that a recombinant Lactobacillus sakei would decrease the complications or symptoms significantly through against different pathogenic mechanisms simultaneously. Therefore, application of higher radiation dose for tumor control would be feasible when co-treating with recombinant Lactobacillus sakei.
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