期刊
MEDICAL HYPOTHESES
卷 82, 期 3, 页码 245-249出版社
ELSEVIER
DOI: 10.1016/j.mehy.2013.10.023
关键词
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资金
- State Major Research Program of China [2012CB944902]
- National Natural Science Foundation of China [81370764]
- Jiangsu projects, China [BL2012009, FXK201221]
- PAPD project
So far, the pathogenesis of Parkinson's disease (PD) remains unclear. Current studies implicate environmental toxins may be potential causes of fetal origin of PD. BPA is a member of the family of estrogenic chemicals existing widely in environment. Significant evidences from animal experimentation have demonstrated that BPA interfere with fetal neurodevelopment. Based on previous reports and our research on EB derived from hESCs, we speculate that maternal exposure to low-dose BPA during gestational period may decrease IGF-1 expression, thus hinder the development of fetal DA neurons, and finally increase the risks of fetal origin of PD. Our hypothesis may shed new light on the pathogenesis of PD and lead to potential preventive treatments. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.
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