期刊
MEDICAL HYPOTHESES
卷 79, 期 5, 页码 639-641出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.mehy.2012.07.042
关键词
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资金
- Scientific and Technological Research Council of Turkey (TUBITAK)
The role of epigenetic mechanisms in cognitive functions and neurological/psychiatric disorders has been studied in a number of studies recently. One of these mechanisms is DNA methylation. for which DNA methyltransferases (DNMT) are responsible. Decitabine, or 5-aza-2'-deoxycytidine, is a cytosine-analog DNMT inhibitor and is used in the treatment of certain myelodysplastic syndromes (MDS) subsets. Several studies address the role of DNA methylation and negative effects of decitabine on memory formation and consolidation in animals. We, therefore, hypothesize that standard decitabine treatment for MDS in patients without dementia might cause learning and memory deficits. A clinical trial is proposed to test the hypothesis which could support the role of DNA methylation in cognitive abilities of humans. (C) 2012 Elsevier Ltd. All rights reserved.
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