期刊
MEDICAL HYPOTHESES
卷 78, 期 3, 页码 398-401出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.mehy.2011.11.019
关键词
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资金
- National Basic Research Development Program of China [2010CB945200]
- Shanghai Key Discipline Program [S30202]
- Shanghai Key Project of Basic Science Research [09DZ1950400]
- Program for Outstanding Medical Academic Leader [Lj 06003]
Recently, there have been increasing evidences that microRNA-146 (miR-146) is related to up-regulated immune and inflammatory signaling through its target genes, such as IRAK1 and TRAF6. Additionally, abundant data continue to support the hypothesis that progressive up-regulation of inflammatory gene expression and elevated inflammatory signaling facilitate the development and progression of Alzheimer's disease (AD). This review focuses on the recent findings regarding the role of miR-146 in modulating immune response and its subsequent effects in the pathogenesis of AD. (C) 2011 Elsevier Ltd. All rights reserved.
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