期刊
MEDICAL HYPOTHESES
卷 70, 期 4, 页码 826-830出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.mehy.2007.07.037
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According to the molecular mimicry theory, multiple sclerosis (MS) develops when the immune system mistakenly attacks a component of the myelin sheath that is structurally similar to a foreign epitope. The glycolipid galactocerebroside (GalC) is a major component of myelin. As lipids comprise between 70% and 85% of myelin, glycolipids should be investigated as candidate autoantigens in MS. GalC displays broad structural similarities to the Borrelia burgdorferi glycotipid antigen BbGL-2 and to the Sphingomonas antigen GalAGSL. In principle, therefore, these bacteria may induce an autoimmune attack on the myelin sheath. GalC is also structurally similar to natural killer T (NKT) cell ligand alpha-galactosylceramide (alpha-GaKer). Further studies must be performed to clarify the role of GalC in the activation of NKT cells and the development of MS. (c) 2007 Elsevier Ltd. All rights reserved.
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