期刊
MEDICAL ENGINEERING & PHYSICS
卷 32, 期 7, 页码 775-782出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.medengphy.2010.05.001
关键词
Additive technologies; Computational mechanics; Scaffolds; Tissue engineering; Topological optimisation
资金
- Portuguese Foundation for Science and Technology [SFRH/BD/37604/2007, PTDC/EME-PME/71436/2006]
- Fundação para a Ciência e a Tecnologia [PTDC/EME-PME/71436/2006, SFRH/BD/37604/2007] Funding Source: FCT
Advanced additive techniques are now being developed to fabricate scaffolds with controlled architecture for tissue engineering. These techniques combine computer-aided design (CAD) with computer-aided manufacturing (CAM) tools to produce three-dimensional structures layer by layer in a multitude of materials. Actual prediction of the effective mechanical properties of scaffolds produced by additive technologies, is very important for tissue engineering applications. A novel computer based technique for scaffold design is topological optimisation. Topological optimisation is a form of shape optimisation, usually referred to as layout optimisation. The goal of topological optimisation is to find the best use of material for a body that is subjected to either a single load or a multiple load distribution. This paper proposes a topological optimisation scheme in order to obtain the ideal topological architectures of scaffolds, maximising its mechanical behaviour. (C) 2010 IPEM. Published by Elsevier Ltd. All rights reserved.
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