期刊
MEDICAL CLINICS OF NORTH AMERICA
卷 97, 期 3, 页码 399-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.mcna.2012.12.013
关键词
Alzheimer disease; Preclinical diagnosis; Magnetic resonance imaging; Functional magnetic resonance imaging; Diffusion tensor imaging; Diffusion spectrum imaging; Multimodal imaging; Prediction
资金
- Katharina-Hardt-Foundation, Bad Homburg, Germany
- Department AGIS of the University of Rostock
Magnetic resonance imaging (MRI)-based indicators of regional and global brain atrophy and more advanced measures of cortical functional and structural connectivity are among the most promising imaging biomarkers for the characterization of preclinical and prodromal stages of Alzheimer disease (AD). This review presents the current status of available and evolving MRI-based technologies for the early asymptomatic and predementia diagnosis of AD, including high-resolution structural MRI of global and regional brain atrophy, diffusion tensor imaging of structural cortical connectivity, and functional MRI during rest and task performance. The selection of an appropriate technique needs to consider its suitability for specific applications.
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