期刊
MEDICAL CARE
卷 48, 期 6, 页码 S52-S57出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MLR.0b013e3181dbebcf
关键词
cluster randomization; comparative effectiveness; MRSA prevention
类别
资金
- NCPDCID CDC HHS [U01CI000344] Funding Source: Medline
Background: The need for evidence about the effectiveness of therapeutics and other medical practices has triggered new interest in methods for comparative effectiveness research. Objective: Describe an approach to comparative effectiveness research involving cluster randomized trials in networks of hospitals, health plans, or medical practices with centralized administrative and informatics capabilities. Research Design: We discuss the example of an ongoing cluster randomized trial to prevent methicillin-resistant Staphylococcus aureus (MRSA) infection in intensive care units (ICUs). The trial randomizes 45 hospitals to: ( a) screening cultures of ICU admissions, followed by Contact Precautions if MRSA-positive, (b) screening cultures of ICU admissions followed by decolonization if MRSA- positive, or ( c) universal decolonization of ICU admissions without screening. Subjects: All admissions to adult ICUs. Measures: The primary outcome is MRSA- positive clinical cultures occurring >= 2 days following ICU admission. Secondary outcomes include blood and urine infection caused by MRSA ( and, separately, all pathogens), as well as the development of resistance to decolonizing agents. Results: Recruitment of hospitals is complete. Data collection will end in Summer 2011. Conclusions: This trial takes advantage of existing personnel, procedures, infrastructure, and information systems in a large integrated hospital network to conduct a low-cost evaluation of prevention strategies under usual practice conditions. This approach is applicable to many comparative effectiveness topics in both inpatient and ambulatory settings.
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